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Title   위암에서 증식세포 핵항원 ( PCNA ) 발현이 예후에 미치는 영향 ( Prognostic Significance of Proliferating Cell Nuclear Antigen ( PCNA )
Publicationinfo   1995 Jan; 027(01): 18-28.
Key_word   Gastric carcinoma, Prognosis, Proliferating cell nuclear antigen(PCNA)
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Abstract   Proliferatina cell nuclear antigen(PCNA) is known to be closely correlated with DNA synthesis and cell proliferation. Proliferative activities of tumors have recently been consid- ered as one of important prognostic factors in a variety of human cancers. A total of 195 gastric carcinomas was evaluated with immunohistochemical study, using an- tibody(PC 10) with special reference to the correlation between PCNA expression and progno- sis. PCNA expression was assessed semi-quantitatively based on the proportion of tumor cells with immunostained nuclei. There was no significant correlation between PCNA expression and clinicopathological variables such as age, sex, tumor site, size, histologic grade, tumor stage, or the presence of lymph node metastases. To analyse survival, we evaluated disease-free survival and overall survival according to the extent of PCNA expression. No significant correlations between PCNA expression and both disease-free survival and overall survival were found. In conclusion, PCNA expression assessed by semi-quantitative PCNA grading system was not a significant prognostic factor in gastric carcinoma.
저 자   임호영(Ho Yeong Lim),김주항(Joo Hang Kim)정현철(Hyun Cheol Chung),엄효동(Hyo Dong Um),최진혁(Jin Hyuk Choi),이기범(Byung Soo Kim),신동환(Dong Hwan Shin),노재경(Jae Kyung Roh),김병수(Byung Soo Kim)